| Barranquilla vs Leones | Colombia Primera B | 19 October 2021 | |
| Envigado vs Rionegro | Colombia Primera A | 18 October 2021 | |
| Atletico Junior vs Jaguares Cordoba | Colombia Primera A | 18 October 2021 | |
| Santa Fe vs Millonarios | Colombia Primera A | 17 October 2021 | |
| Alianza Petrolera vs Atl. Bucaramanga | Colombia Primera A | 17 October 2021 | |
| Deportivo Pasto vs Deportes Quindio | Colombia Primera A | 17 October 2021 | |
| Atletico Nacional vs Ind Medellin | Colombia Primera A | 17 October 2021 | |
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