| Independiente M vs Deportive Cali | Colombia Primera A | 26 February 2021 | |
| Alianza Petrolera vs Deportes Tolima | Colombia Primera A | 25 February 2021 | |
| Jaguares Cordoba vs Deportivo Pereira | Colombia Primera A | 25 February 2021 | |
| Once Caldas vs Deportivo Pasto | Colombia Primera A | 25 February 2021 | |
| America de Cali vs Envigado | Colombia Primera A | 25 February 2021 | |
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