| Boca Juniors vs Deportivo Cali | CONMEBOL Copa Libertadores | 27 May 2022 | |
| Corinthians vs Always Ready | CONMEBOL Copa Libertadores | 27 May 2022 | |
| Atletico Junior vs Union de Santa Fe | CONMEBOL Copa Sudamericana | 27 May 2022 | |
| Oriente Petrolero vs Fluminense | CONMEBOL Copa Sudamericana | 27 May 2022 | |
| Athletico-PR vs Caracas | CONMEBOL Copa Libertadores | 26 May 2022 | |
| Libertad vs The Strongest | CONMEBOL Copa Libertadores | 26 May 2022 | |
| Cerro Porteno vs Olimpia | CONMEBOL Copa Libertadores | 26 May 2022 | |
| Atletico-MG vs Deportes Tolima | CONMEBOL Copa Libertadores | 26 May 2022 | |
| Independiente vs America Mineiro | CONMEBOL Copa Libertadores | 26 May 2022 | |
| Penarol vs Colon Santa Fe | CONMEBOL Copa Libertadores | 26 May 2022 | |
| Melgar vs Cuiaba | CONMEBOL Copa Sudamericana | 26 May 2022 | |
| Racing vs River Plate M | CONMEBOL Copa Sudamericana | 26 May 2022 | |
| Deportivo La Guaira vs General Caballero | CONMEBOL Copa Sudamericana | 26 May 2022 | |
| Independiente vs Ceara | CONMEBOL Copa Sudamericana | 26 May 2022 | |
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