| Tenerife vs Eibar | Spain Segunda Division | 19 October 2021 | |
| Huesca vs Malaga | Spain Segunda Division | 19 October 2021 | |
| Cartagena vs Sporting Gijon | Spain Segunda Division | 19 October 2021 | |
| Espanyol vs Cadiz | Spain Primera Division | 18 October 2021 | |
| Alaves vs Real Betis | Spain Primera Division | 18 October 2021 | |
| Barcelona vs Valencia | Spain Primera Division | 17 October 2021 | |
| Villarreal vs Osasuna | Spain Primera Division | 17 October 2021 | |
| Celta Vigo vs Sevilla | Spain Primera Division | 17 October 2021 | |
| Rayo Vallecano vs Elche | Spain Primera Division | 17 October 2021 | |
| Ponferradina vs Fuenlabrada | Spain Segunda Division | 17 October 2021 | |
| Real Sociedad II vs Real Oviedo | Spain Segunda Division | 17 October 2021 | |
| Burgos vs Lugo | Spain Segunda Division | 17 October 2021 | |
| Leganes vs Valladolid | Spain Segunda Division | 17 October 2021 | |
| Ibiza vs Mirandes | Spain Segunda Division | 17 October 2021 | |
| Real Sociedad Women vs Levante Women | Spain Women Primera Division | 17 October 2021 | |
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