| Real Betis vs Getafe | Spain Primera Division | 26 September 2021 | |
| Real Sociedad vs Elche | Spain Primera Division | 26 September 2021 | |
| Rayo Vallecano vs Cadiz | Spain Primera Division | 26 September 2021 | |
| Barcelona vs Levante | Spain Primera Division | 26 September 2021 | |
| Mallorca vs Osasuna | Spain Primera Division | 26 September 2021 | |
| Valladolid vs Alcorcon | Spain Segunda Division | 26 September 2021 | |
| Lugo vs Zaragoza | Spain Segunda Division | 26 September 2021 | |
| Real Oviedo vs Girona | Spain Segunda Division | 26 September 2021 | |
| Sporting Gijon vs Malaga | Spain Segunda Division | 26 September 2021 | |
| Mirandes vs Leganes | Spain Segunda Division | 26 September 2021 | |
| Real Madrid vs Villarreal | Spain Primera Division | 25 September 2021 | |
| Sevilla vs Espanyol | Spain Primera Division | 25 September 2021 | |
| Valencia vs Athletic Bilbao | Spain Primera Division | 25 September 2021 | |
| Alaves vs Atletico Madrid | Spain Primera Division | 25 September 2021 | |
| Las Palmas vs Ponferradina | Spain Segunda Division | 25 September 2021 | |
| Amorebieta vs Eibar | Spain Segunda Division | 25 September 2021 | |
| Ibiza vs Burgos | Spain Segunda Division | 25 September 2021 | |
| Villarreal III vs Atletico Saguntino | Spain Tercera Division | 25 September 2021 | |
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