| Uzhgorod vs Chayka PB | Ukraine Second League | 14 April 2021 | |
| Bukovyna vs Nyva Vinnytsia | Ukraine Second League | 14 April 2021 | |
| Tavriya Simferopol vs Metalurh Z | Ukraine Second League | 14 April 2021 | |
| Peremoga vs Metal | Ukraine Second League | 14 April 2021 | |
| Volyn-2 vs Chernihiv | Ukraine Second League | 14 April 2021 | |
| Yarud vs Balkany Zorya | Ukraine Second League | 14 April 2021 | |
| Karpaty vs Karpaty Galic | Ukraine Second League | 14 April 2021 | |
| Real Pharma vs Dnepr Cherkasy | Ukraine Second League | 13 April 2021 | |
| Epitsentr Dunayivtsi vs Rubicon | Ukraine Second League | 13 April 2021 | |
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