| Chernomorets vs Veres | Ukraine Premier League | 18 October 2021 | |
| Agrobiznes Volochysk vs Metalist | Ukraine First League | 18 October 2021 | |
| Rubicon vs Dnepr Cherkasy | Ukraine Second League | 18 October 2021 | |
| Oleksandria vs Vorskla | Ukraine Premier League | 17 October 2021 | |
| Minai vs Desna | Ukraine Premier League | 17 October 2021 | |
| Alians Lypova Dolyna vs Uzhgorod | Ukraine First League | 17 October 2021 | |
| Hirnyk-Sport vs Volyn | Ukraine First League | 17 October 2021 | |
| Peremoga vs Viktoria Mykolaivka | Ukraine Second League | 17 October 2021 | |
| Levyy Bereg vs Karpaty Galic | Ukraine Second League | 17 October 2021 | |
| Yarud vs Real Pharma | Ukraine Second League | 17 October 2021 | |
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