| Vancouver vs Kansas City | USA MLS | 18 October 2021 | |
| LA Galaxy II vs El Paso Locomotive | USA USL | 18 October 2021 | |
| New York vs New York City | USA MLS | 17 October 2021 | |
| LA Galaxy vs Portland | USA MLS | 17 October 2021 | |
| Real Salt Lake vs Colorado | USA MLS | 17 October 2021 | |
| Austin vs Minnesota | USA MLS | 17 October 2021 | |
| Houston Dynamo vs Seattle | USA MLS | 17 October 2021 | |
| OKC Energy vs Birmingham Legion | USA USL | 17 October 2021 | |
| San Diego Loyal vs New Mexico United | USA USL | 17 October 2021 | |
| Sacramento Republic vs Tacoma Defiance | USA USL | 17 October 2021 | |
| Oakland Roots vs Orange County | USA USL | 17 October 2021 | |
| San Antonio vs Tulsa | USA USL | 17 October 2021 | |
| Colorado Springs vs Rio Grande Valley | USA USL | 17 October 2021 | |
| Fort Lauderdale vs North Texas | USA USL League One | 17 October 2021 | |
| Tucson vs Tormenta | USA USL League One | 17 October 2021 | |
| OL Reign (W) vs Washington Spirit (W) | USA Women NWSL | 17 October 2021 | |
| Chicago Red Stars (W) vs Kansas City (W) | USA Women NWSL | 17 October 2021 | |
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