| Las Vegas Lights vs El Paso Locomotive | USA USL | 28 May 2022 | |
| Atlanta Utd II vs Orange County | USA USL | 27 May 2022 | |
| NY Red Bulls II vs Birmingham Legion | USA USL | 27 May 2022 | |
| Sacramento Republic vs San Jose | USA US Open Cup | 26 May 2022 | |
| LA Galaxy vs Los Angeles | USA US Open Cup | 26 May 2022 | |
| Kansas City vs Houston Dynamo | USA US Open Cup | 26 May 2022 | |
| NY Red Bulls vs Charlotte | USA US Open Cup | 26 May 2022 | |
| Minnesota Utd vs Union Omaha | USA US Open Cup | 26 May 2022 | |
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